3D STRUCTURES FOR TISSUE ENGINEERING

Abstract: 

Micro/nanostructuring technologies have now reached a level of development and maturity that allows them to be described as production technologies. They employ novel materials, high-tech equipment, and demonstrate high-throughput and repeatability. Three dimensional structuring of photosensitive polymers has evolved, from classic stereolithography with a resolution of 300 microns, to femtosecond laser nonlinear lithography with sub-100nm resolution. To date, however, research into materials for microfabrication has been limited to obtaining satisfactory qualitative results, while research into the changes of the material during micro-processing is still at an early stage.

The main two objectives of the research proposed here are:

  1. The synthesis and study of a range of photosensitive bio-compatible polymers suitable for fabrication using nonlinear micro-stereo lithography. Furthermore, the investigation of the design and manufacture of precise 3D micro-structures using these materials. An important characteristic of these will be the lack of geometric distortions due to shrinkage during processing and low surface roughness. To this end, new experiments will be designed and developed to measure the shrinkage (using a fiber optic sensor) and roughness of the microstructures in situ, during fabrication. The in-situ monitoring of these phenomena during the solidification of the polymer is important for reliable, single-step fabrication of functional microstructures.
  2. The employment of the above materials and monitoring techniques for the fabrication of 3D scaffolds for the development of skin and bone tissue. These will be manufactured by nonlinear micro-stereolithography and their size and resolution will be consistent with the size of the cells. The deliverables of this project will be (i) materials and structures for use as scaffolds for the development of skin and bone tissue, and (ii) techniques for monitoring the scaffold fabrication.

 

3DSET / Mis: 380278

 

Project info

Acronym:
3DSET
Scientific Coordinator:
Farsari Maria
Research Team 2 Leader:
Karalekas Dimitrios
Research Team 3 Leader:
Chatzinikolaidou Maria

Stats

I.D.:
473
Mis:
380278
Duration (months):
43
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β43Ι9-ΜΡ5

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