THE GENETIC ARCHITECTURE OF TYPE 2 DIABETES MELLITUS IN THE GREEK POPULATION; SUSCEPTIBILITY, MANAGEMENT, AND PREDICTION OF COMPLICATIONS

Abstract: 

Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disorder that is caused by the interplay among genetic background and environmental factors. The prevalence of T2DM around the world is reaching the levels of an epidemic. T2DM remains the leading cause of renal failure and blindness and is associated with more than 15% of public health costs. A focal point of the strategic planning of programs for the prevention of the onset of T2DM, and related complications and personalized treatment, is the exploration of the genetic architecture of T2DM.

Aim: The main objective of this study is the investigation of the genetic architecture of T2DM in the Greek population, as related to all the different stages of the natural history of the disorder; from genetic susceptibility and symptom development to individualized pharmacological treatment and predisposition for the development of specific complications (diabetic nephropathy and diabetic retinopathy).

Work Packages:

  • A biobank of DNA samples from 2,000 individuals with T2DM and controls is going to be established, and 1,000 carefully selected genetic markers will be analyzed.
  • Patients will be carefully recruited in order to correlate genetic background with disease onset as well as the pharmacogenetics of metformin and the sulphonylureas.
  • A significant part of the study will deal with the development of novel statistical tools for the analysis of genomewide data and the meta-analysis of results from published genomewide association studies in this field.
  • Finally, dissemination, raising awareness about T2DM prevention, and education of health professionals, will be central tasks of our project.

Expected results:

  • This study will set the basis for the use of individual genetic profiling in the strategic planning of T2DM prevention programs for the Greek population as well as individualized disease management.
  • Understanding the genetic underpinnings of T2DM will eventually lead to improved treatments and care.

Project info

Acronym:
GREEKDIAGENES
Coordinating Institution:
Democritus University of Thrace (DUTH)
Scientific Coordinator:
Paschou Peristera
Research Team 2 Leader:
Vargemezis Vassilios
Research Team 3 Leader:
Maltezos Efstratios
Research Team 4 Leader:
Yovos Ioannis
Research Team 5 Leader:
Patrinos George
Research Team 6 Leader:
Tsakalidis Athanasios

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