MICRORNAS AND TRANSCRIPTION FACTOR NETWORKS IN THE REGULATION OF CELL DIFFERENTIATION, AGING AND TUMORIGENESIS

Abstract: 

MicroRNAs are promising targets in biomedical research because of their role in the regulation of gene expression. Mature miRNA molecules pair with mRNAs causing their degradation or translational repression. Because of their multiplicity and complex regulation, networking and target specificity, they are involved in diverse physiological processes including hematopoiesis, developmental timing, cell differentiation and proliferation, apoptosis and organ development.

Exploiting and further advancing knowledge on their role in biological processes will offer answers but also biomedical tools for fundamental biological processes. We have established a research consortium that will employ high throughput genomic and proteomic approaches, in addition to molecular, cellular and genetic studies, to investigate the role and interplay of miRNAs with protein coding genes in the regulation of cell differentiation, DNA damage/aging and tumorigenesis.

More specifically, we will:

  • Examine the role of miRNA in the regulation of embryonic stem cell differentiation and the establishment of stemness in breast and neural cancers,
  • Study the deregulation of miRNAs as a consequence of DNA damage or tumor progression,
  • Elucidate how the intra-nuclear topology can regulate the expression of microRNA loci and their synergy with transcription factors and
  • Identify miRNAs as targets for the development of tools for molecular diagnosis and therapy in the cases of cancer or cell aging.

By capitalizing on strong track record, complementarity of approaches, previous and current collaborations and use of high throughput genomic and proteomic approaches, the consortium will identify and study the actions of microRNAs in stem/progenitor cell pluripotency and self renewal, cancer stem cell activity, immune differentiation and cell aging. New knowledge will lead to the development of novel miRNA-based tools and gene targets for molecular diagnosis or therapy.

Project info

Acronym:
miREG
Scientific Coordinator:
Papamatheakis Joseph
Research Team 2 Leader:
Spilianakis Charalampos
Research Team 3 Leader:
Michailidis Theologos

Stats

I.D.:
1435
Mis:
380247
Duration (months):
41
Budget:
575 523.00

Document Library

News

(6/7/2012) Ένταξη της Πράξης «ΘΑΛΗΣ- ΙΔΡΥΜΑ ΤΕΧΝΟΛΟΓΙΑΣ & ΕΡΕΥΝΑΣ Λειτουργικά δίκτυα μικρο-RNA και μεταγραφικών ρυθμιστών στη ρύθμιση της διαφοροποίησης, γήρανσης και ογκογένεσης», με MIS: 380247 στο Επιχειρησιακό Πρόγραμμα «ΕΚΠΑΙΔΕΥΣΗ ΚΑΙ ΔΙΑ ΒΙΟΥ ΜΑΘΗΣΗ» 2007-2013. - ΑΠ10 (PDF|2,6 MB)