GLUTATHIONE TRANSFERASES: MULTIFUNCTIONAL MOLECULAR TOOLS IN RED AND GREEN BIOTECHNOLOGY

Abstract: 

Glutathione transferases (GSTs) are phase II detoxification enzymes that catalyze the conjugation of glutathione (GSH) to xenobiotics and endogenous electrophilic compounds, leading to cellular detoxification. Detailed studies of GSTs are justified because of the considerable interest of these enzymes in agriculture and medicine. Plant GSTs (green biotechnology) attract significant attention as they contribute to defence against oxidative injury during various biotic and abiotic stresses in plants. In medicine (red biotechnology), many anticancer drugs are substrates for human GSTs and, therefore, GSTs are explored as molecular targets for the design of new anticancer drugs against drug-resistant tumours that overexpress GSTs.

The GST-TOOLS consortium, will apply a multidisciplinary scientific approach that aims to:

  • examine and explore the genetic, catalytic and structural diversity of GSTs from indigenous stress-tolerant plants from extreme environments in order to identify and engineer novel GST isoenzymes with innovative catalytic properties and detoxifying roles,
  • apply combinatorial de novo design, synthesis and high-throughput screening for the development of new pharmaceutically active GST inhibitors with anticancer properties.

The results of the GST-TOOLS project will provide an in depth and up-to-date data on the structure, function and biological role of the GST enzyme family, and will apply this knowledge to develop high-added value products with applications in plant breeding for sustainable crop production, anticancer drug design and cosmetology. The integration of advanced research with a planed efficient mechanism for knowledge transfer, training and dissemination will contribute significant to the objectives that have been set out at national and European level and focused on: identification and sustainable use of metabolic and genetic diversity as a source of new valuable products in green economy.

Project info

Acronym:
GST-TOOLS
Coordinating Institution:
Agricultural University of Athens
Scientific Coordinator:
Labrou Nikolaos
Research Team 2 Leader:
Cordopatis Paul
Research Team 3 Leader:
Tsaftaris Athanasios
Research Team 4 Leader:
Madesis Panagiotis

Stats

I.D.:
83
Mis:
380236
Duration (months):
47
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β4169-Ι6Υ

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