HETEROGENEITY OF AUTOIMMUNE DISEASES: UNDERSTANDING OF DISEASE-SPECIFIC AND PATIENT-SPECIFIC MECHANISMS

Abstract: 

Autoimmune diseases cause considerable and long term disability, imposing a major social and economic burden; they can present from childhood to old age, while very often they cause life-long morbidity. Under the current proposal we intend to investigate several aspects of autoimmunity focusing on model autoimmune diseases, both organ-specific (myasthenia gravis, multiple sclerosis, neuromyelitis optica, chronic inflammatory demyelinating polyneuropathy, autoimmune limbic encephalitis) and systemic (Sjogren's syndrome) disorders.

Our choice to study what seems to be a diverse group of autoimmune diseases is based on our main aim, namely to identify common factors and pathways influencing autoimmunity in general, and this can only be achieved by comparatively studying different autoimmune disorders. Moreover, the participating groups already have extensive research and clinical expertise on these disorders.

The project is designed to integrate new technologies and approaches, to identify genetic influences on autoimmunity, to develop technologies for the identification and study of new antigenic targets, to establish the pathogenicity and relevance of the antibodies in the diseases under study, and to improve and develop new diagnostic approaches.

The results of this project will contribute considerably to the improvement of the diagnosis and management of these diseases, hence contributing significantly towards the well-being of the patients.

Project info

Acronym:
AUTOIMMUNITY
Coordinating Institution:
University of Patras
Scientific Coordinator:
Tzartos Socrates
Research Team 2 Leader:
Tzioufas Athanasios
Research Team 3 Leader:
Germenis Anastasios

Stats

I.D.:
1089
Mis:
380221
Duration (months):
45
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β4169-76Ζ

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