SYNTHESIS AND CHARACTERIZATION OF NEW NANOSTRUCTRURED GEOPOLYMERS AND CALCIUM PHOSPHATE BASED BIOCEMENTS AND IMPLANTS

Abstract: 

Medical surgeons nowadays are increasing their demand on new types of materials for implementation in cases of bone fracture or deficiencies resulted from accidents, cysts, tumors, and other bone diseases. These implants are made by several types of materials such as organic and inorganic cements. Their main characteristics are biocompatibility, bone regeneration if possible and the ability to withstand mechanical loading.

Main purpose of this study is to examine new types of advanced nanostructured bone cements with high osteoinductivity and osteoconductivity. These will be based on calcium phosphate matrices with or without reinforcements of in-vitro synthesized nano-needles of hydroxyapatite. Effort shall be also invested to manufacture bone cements based on geopolymer matrices. Both types of nano-composite new bone cements are expected to exhibit high mechanical properties, enabling them to act as bone substitutes.

The project is organized in fourteen scientific workpackages plus an administration & management workpackage. The workpackages are divided into four main categories:

  • Synthesis and Characterization,
  • Mechanical Characterization,
  • Micromechanical Response and
  • Biomedical Response.

The structure of these workpackages ensures successful completion of the project as well as effective cooperation between the research sub-groups. Successful completion of the above described project is expected to deliver significant progress in the field of calcium phosphate biocements and geopolymer bone cements with nanophase reinforcements such as hydroxyapatite needles, possibly leading to new products in this area with high mechanical properties, for orthopedic and dental surgery applications. Another outcome of the project will be the incorporation in the new bone cements pharmaceutical substances such as antibiotics. This combination will lead to better healing results due to the minimalization of the post-surgical infection risk.

Project info

Acronym:
NANO.GEO.S.CA.PHO.L
Scientific Coordinator:
Mouzakis Dionysis
Research Team 2 Leader:
Bouropoulos Nikolaos
Research Team 3 Leader:
Zaoutsos Stefanos
Research Team 4 Leader:
Karalekas Dimitrios
Research Team 5 Leader:
Douni Eleni
Research Team 6 Leader:
Papadopoulos Triantafyllos

Stats

I.D.:
945
Mis:
379380
Duration (months):
45
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β4ΛΔ9-Θ4Ψ

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