"SMART" MAGNETIC NANOPARTICLES PROBES FOR MAGNETIC RESONANCE IMAGING (MRI)

Abstract: 

Magnetic resonance imaging, MRI,has been recognized as the most important non-invasive technique in medical diagnosis. Several imaging chemicals, known as MRI contrast agents, have been developed to enhance the visual observation with a better contrast. Nanotechnology provided the advances to the development of new type of contrast agents based on magnetic nanoparticles (MNP). For this purpose, nanoparticles must have combined properties of high magnetization and functions in the surface area.

We focus on tailoring MNP as versatile probes for MRI through controlling the magnetism of the nanoparticle core and designing the surface ligands of the nanoparticle shell to attain high performance utilizations together with colloidal stability.

The main goals are:

  • targeted-controlled synthesis of hydrophobic and hydrophilic MNP of different composition, size, shape,
  • biofunctionalisation of MNP with new amphiphilic polymeric compounds,
  • synthesis of polymeric compounds for the provision of water solubility,
  • multifunctionalisation of MNP with copper ions,
  • structural and magnetic characterization,
  • evaluation of the MNP as probes for MRI contrast agents.

Synthetic processes of MNP will be based on a bottom up approach through wet chemical synthesis that provides the ability to control precisely the composition, structure, size of MNP and to allow for high performance utilizations. For the surface ligands we will develop polymeric compounds in order to provide a physical barrier to prevent aggregation, to increase the hydrodynamic size providing long-term stability. MNP contrast enhancement will be studied in topics where current imaging techniques is not satisfactory. In-vitro experiments will be achieved in simulated phantoms. In-vivo evaluation will be obtained in various organs, normal and pathological tissues.The proposed research will be conducted through an innovative approach involving Chemistry, Physics, Materials Science and Medicine in the field of nanodiagnostics.

Project info

Acronym:
Smart-MNPs
Coordinating Institution:
Aristotle University of Thessaloniki
Scientific Coordinator:
Dendrinou-Samara Catherine
Research Team 2 Leader:
Dendrinou-Samara Catherine
Research Team 3 Leader:
Bokias George
Research Team 4 Leader:
Kalogirou Orestis
Research Team 5 Leader:
Vassiou Katerina

Stats

I.D.:
226
Mis:
377339
Duration (months):
44
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β4ΛΑ9-Ε05

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