BIOACTIVITY OF AIRBORNE PARTICULATES IN RELATION WITH THEIR SIZE, MORPHOLOGY AND CHEMICAL COMPOSITION

Abstract: 

Airborne particles in the urban atmosphere range from a size of less than 0.1m (ultrafine particles) up to more than 10m (coarse particles). Typical examples are emissions from combustion sources (traffic, domestic heating, power generation), resuspended dust, marine aerosol, as well as secondary particles formed by photochemical reactions of gaseous pollutants. Airborne particles with d 10m may enter the human respiratory tract with the sizes<2.5m penetrating deeper into the lungs. Particles with d<1m reach the alveoli where are deposited by sedimentation and diffusion mechanisms.

Recent epidemiological surveys have documented strong correlation between elevated mass concentrations of airborne particles and short and long term health effects in urban populations (bronchitis, pneumonia, worsening of childhood asthma or chronic obstructive respiratory disease, and cardiovascular disease). However, there is poor link between health effects and particle characteristics, nor is there sufficient knowledge of the biological mechanisms occurring on the lung tissues, or the bronchial and the alveolar epithelium. The proposed research is a comprehensive interdisciplinary study of the bioactivity of airborne particulate matter in urban areas.

Major objectives are:

  • the development and standardization of combined methods for identification of the health responses (inflammatory, toxic, mutagenic, carcinogenic, endocrine, etc) induced by airborne particles and specific chemical components,
  • the association of the ability of urban particles to induce biological effects with their physicochemical characteristics (mass concentration, number concentration, size distribution, surface area, chemical composition, etc), and
  • the association of particle bioactivity with specific anthropogenic sources.

Project info

Acronym:
BIOACTAIR
Coordinating Institution:
Aristotle University of Thessaloniki
Scientific Coordinator:
Samara Constantini
Research Team 2 Leader:
Samaras Zissis
Research Team 3 Leader:
Moustaka-Gouni Maria
Research Team 4 Leader:
Pantazaki Anastasia
Research Team 5 Leader:
Lialiaris Theodoros
Research Team 6 Leader:
Emmanouil-Nikoloussi Elpida-Niki

Stats

I.D.:
637
Mis:
377304
Budget:
587 664.00

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