IDENTIFICATION OF REPRODUCTIVE, SOMATOMETRIC, NUTRITIONAL AND OTHER FACTORS RESPONSIBLE FOR THE SECULAR INCREASE OF BREAST CANCER INCIDENCE IN GREECE

Abstract: 

Background: Notwithstanding improvements in treatment, breast cancer mortality is increasing in Greece, in contrast to other European Union countries, pointing to a secular increase in the incidence of the disease.

Aim: To identify factors responsible for the apparent secular increase in breast cancer incidence, using primary data from five major breast cancer epidemiological studies undertaken in Greece by investigators in the applicant group between the mid 1960s and mid 2000s. The identified factors will be validated in a new case-control study, the protocol of which will be fine-tuned to accommodate the evidence from the five earlier studies.

Workpackages:

  1. Retrieval of the primary data from five Greek epidemiological studies on breast cancer covering a period of more than four decades.
  2. Development of an integrated database comprising comparable data from the five studies.
  3. Development of the protocol of the new study which will validate the evidence from the earlier investigations.
  4. Training of health visitors on data collection for the new study.
  5. Data collection for the new epidemiological study.
  6. Measurement of hormones in order to evaluate their role as possible mediators of the long-term changes in the implicated risk factors.
  7. Epidemiological analysis, statistical evaluations and drafting of scientific papers.
  8. Coordination of the work of the collaborating institutions.
  9. Internal evaluation of the progress of the research plan.

Expected results: Identification and quantitative assessment of reproductive, somatometric, nutritional and other factors responsible for the secular increase of breast cancer incidence in Greece and evaluation of a possible mediating role of selected endocrine factors. The results could help outline corrective interventions in the context of primary prevention or identification of high risk groups for secondary prevention.

 

Mis: 377048

Project info

Acronym:
SIBRIN
Scientific Coordinator:
Lagiou Areti
Research Team 2 Leader:
Lagiou Pagona
Research Team 3 Leader:
Trichopoulos Dimitrios

Stats

I.D.:
992
Mis:
377048
Duration (months):
45
Budget:
576 664.00
Diavgeia:
ΑΔΑ: Β4ΛΞ9-ΙΟΤ

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