MATURATION OF INNATE IMMUNITY: INFLUENCE OF INFECTIONS AND ROLE IN THE DEVELOPMENT OF ALLERGY AND ASTHMA

Abstract: 

BACKGROUND: Respiratory allergies such as asthma occur as a result of inappropriate Th2-mediated immune responses to common aeroallergens in genetically susceptible individuals. Recently, new risk factors for disease development beyond Th2-mediated allergic sensitization have emerged. Among them, rhinovirus (RV) infections during the first years of life appear to be crucial, as they increase the risk of children to develop asthma even more than allergic sensitization. However, how this occurs remains unknown.

AIMS: This programme will evaluate the hypothesis that defective maturation of innate immunity in early life, influenced by infections, contributes to the development of respiratory allergies. It will investigate the interplay between exposure and sensitivity to infections, maturation of the innate immune system in relation to age, and development/persistence of asthma and rhinitis.

WORK PACKAGES (WP):

  • In WP1, a cross-sectional cohort of normal and atopic individuals will be studied whereas,
  • in WP2 a cohort of normal and atopic children will be followed longitudinally for two years.
  • In WP3, innate responses of respiratory epithelial cells from children and adults will be evaluated.
  • In WP4 and WP5 experimental mouse models of RV infection and allergic airway disease will be used.
  • In all cases, parameters of innate immunity, persistence of inflammation and vulnerability to infections will be evaluated in relation to age and episodes of wheezing/asthma.

EXPECTED RESULTS: This study will provide detailed information about the maturation of innate immunity in healthy and atopic individuals, the influence of infections, the development/persistence of allergic responses in the airways, the association of viral infections with microbial colonization, and the role of respiratory epithelium and airway remodelling in the development of allergy and asthma. New molecular pathways with important diagnostic and therapeutic implications will be identified.

 

MIDAS / MIS 377047

 

Project info

Acronym:
MIDAS
Scientific Coordinator:
Andreakos Evangelos
Research Team 2 Leader:
Papadopoulos Nikos
Research Team 3 Leader:
Loukides Stylianos

Stats

I.D.:
107
Mis:
377047
Duration (months):
43
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β4Λ39-ΣΤ0

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