BIOLOGICAL EFFECTS OF NON-IONIZING ELECTROMAGNETIC FIELDS: A MULTIDISCIPLINARY APPROACH

Abstract: 

We are exposed to electromagnetic radiation throughout our lives, even prenatally. This proposal aims to throw light into the understanding of its biological effects, which may underlie serious health hazards, as the one announced by World Health Organization recently about the possible carcinogenic capacity (grade 2B) of mobile phone radiation.

We have concentrated our research into two highly used by the modern society spectral regions,

  1. the wireless communication frequencies including mobile and wireless phones and
  2. the ultraviolet (UV) radiation (A/B/C).

The implementation of this task requires first, researchers of high quality and specialization directly recruited by the enormous potential of University of Athens, NCSR Demokritos and BRFAA Research Institutes and second, model systems to retrieve the response of the radiation impact. As such, the insect D. melanogaster, the nematode C. elegans, the small mammal Mus musculus and cells from human skin cancers have been selected, since they are widely used in modern biological research to answer basic and advanced questions related to gene function, behavior, stress, senescence, apoptosis and cell signalling. Clinical studies on people are also scheduled. Platforms of comparative proteomics and xenograft models of human melanoma cells will be applied.

The expected results include:

  1. dose- and/or duration-/repetition-dependent stress response in all kinds of biological systems;
  2. short term and/or long term effects on memory in mice, Caenorhabditis and Drosophila;
  3. anatomical, histological and structural alterations in critical brain tissues and also during embryogenesis in mice;
  4. gene and protein expression changes in mice and C. elegans;
  5. structural and functional modifications of enzymes and other molecules;
  6. elucidation of the genotoxic but also the photodynamic role in human cutaneous tumors of UV radiation;
  7. critical apoptotic and signalling responses to UV (A/B/C)-mediated stress in normal and skin cancer cells.

BENIR-MDA / 375784

 

Project info

Acronym:
BENIR-MDA
Scientific Coordinator:
Margaritis Lukas
Research Team 2 Leader:
Syntichaki Popi
Research Team 3 Leader:
Voutsinas Gerasimos

Stats

I.D.:
525
Mis:
375784
Duration (months):
44
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β4ΩΚ9-6ΞΧ

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