ANALYSIS OF MECHANISMS OF IMMUNOPATOGENESIS IN NATURAL AND EXPERIMENTAL INFECTIONS OF FISH ITH NODA VIRUS: IMPORTANCE OF THE INFECTION FOR PUBLIC HEALTH

Abstract: 

Abstract Greece is the larger producer of sea bream and sea bass in Europe. Greek production reaches 66% of European Union production (approximately 120.000 tons in 2007). More than 80% of production value and 76% of production volume is exported abroad sustaining an important financial profit for Greece. In 2007, sea bream and sea bass were the most important export products for Greece even more important than olive oil (Greek mariculture federation, 2008.) Greek aquaculture, however, is facing disease problems affecting farmed fish. The Mediterranean sea bass is particularly sensitive to viral nervous necrosis (VNN) or otherwise known as encephalopathy and retinopathy virus (VER). The genera Betanodavirus of the Nodaviridae family, causes these serious viral diseases that result to large mass mortalities in farming sea bass that could reach up to 40% of total production and thus having serious financial impact for the industry. So far there is neither effective treatment nor preventive vaccine available.

The aim of this proposal is to assess the epidemiology, the virulence and the genetic diversity of Noda virus infection in Greek farmed fish and in fisheries in order to investigate the presence of this virus in farmed fish as well as in other aquatic organisms (i.e. bivalves) that play a crucial role for the transmission of the virus to healthy fish either to the commercial intensive aquacuculture or to wild fish and fisheries. In parallel, immunopathology, identification of cellular and molecular markers related to disease will be elaborated in experimentally infected sea bass. Possible protective effect of oregano essential oil supplemented feed against Noda virus will also be tested.

These studies will expand our knowledge in the Noda virus epidemiology and immunopathology and most importantly in the identification of diagnostic indicators and potential therapeutic treatments.

Project info

Acronym:
NODAfish
Coordinating Institution:
University of Thessaly
Scientific Coordinator:
Athanassopoulou Fotini
Research Team 2 Leader:
Papanastasopoulou Maria
Research Team 3 Leader:
Karagouni Evdokia

Stats

I.D.:
946
Mis:
375267
Duration (months):
41
Budget:
600 000.00
Diavgeia:
ΑΔΑ: Β4ΩΡ9-94Ζ

Document Library

News