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DEVELOPMENT OF BIOACTIVE PEPTIDES AND ANALOGUES

The wide range of applications of synthetic peptides observed today, exists largely due to the achievements of Chemistry in the field of peptide synthesis, which is an integral part of biomedical and pharmacochemical research.

The vision and at the same time the idea of synthesizing peptides / proteins was born at the beginning of the 20th century, when the huge importance of these compounds in the structure and functioning of living organisms became evident.

In particular, synthetic peptides today are applied in order to regulate the reproduction and development, to control the pain, to deal with the cancer and autoimmune diseases, to treat the cardiovascular disease, to offer diagnostic assistance, etc. Over the last years, the members of Laboratory of Pharmacognosy and Chemistry of Natural Products from the Faculty of Pharmacy at the University of Patras have focused on the design and molecular modeling of peptides and analogues and their synthetic production.

Peptides: unique tools for the development of therapeutic and diagnostic means

CONTEMPORARY REVOLUTION OF PEPTIDE CHEMISTRY

In 1991 through the Stride-Hellas program, the Unit of Synthetic Peptides was developed in the Laboratory, with main research quest the Chemistry of Analogues, Peptides and the Bioactive Peptides’ development for research and other purposes. Since 1996 and every two years, the International Conference “Hellenic Forum on Bioactive Peptides” is organized in Patras, under the auspices of the European Peptide Society. Since 2006 the Laboratory has established and applies a Quality Management System for Educational and Research of processes in DIN EN ISO 9001:2008 by TUV-Austria. Since 2006, the laboratory participates in the Conco international program, in order to discover and develop new therapeutic molecules issued by the venomous species of the sea snail known as ‘Conus consors’. Through deep and exhaustive investigation of animal biodiversity and their genome, the researchers of the program aim to the exploitation (in a sustainable manner) of this great wealth offered by these animals in order to discover the drugs of tomorrow.

This specific scientific field can meet the challenge inspired by the great heritage of our country, the achievements of chemistry and biology. The peptides may be the only means of molecular recognition available in Nature. Therefore, the "peptide revolution" of the third millennium will be impressive as regards the basic research and drug discovery and diagnostics.

EUROPEAN COMMISSION
CONCO
an Integrated Project (FP6)
MARIE CURIE ACTIONS (FP7)

The Laboratory of Pharmacognosy & Chemistry of Natural Products at the University of Patras, has received significant funding through international competitive research and technology programs:

» EC-FP6-2007-2011, Lifeshealth-6 Integrated Project CONCO. Head of Research Team & WP leader for Greece, Professor Mr. Paul Cordopatis (500 kEuro).

» Μarie Curie European Registration Grant: FP7-PEOPLE-ERG-2008 (2009-2011). Scientific Director, Professor Mr. Paul Cordopatis. Grant Holder: Dr. Athanassios Galanis).

UNIVERSITY OF PATRAS

Partners of the Laboratory of Pharmacognosy & Chemistry of Natural Products (Unit of Synthetic Peptides): Assimomytis Nikos - Research Associate, Galanis Athanassios - Post-doc researcher, Zompra Aikaterini - Post-doc researcher, Paul Cordopatis - Professor, Laboratory Director, Lamari Fotini - Associate Professor, Magafa Vasiliki - Assistant Professor.

www.pharmacognosy.upatras.gr